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KMID : 1140220130180030227
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대한암예방학회지
2013 Volume.18 No. 3 p.227 ~ p.234
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Epigenetic Therapies as a Promising Strategy for Overcoming Chemoresistance in Epithelial Ovarian Cancer
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Suh Dong-Hoon
Kim Mi-Kyung
Kim Hee-Seung
Chung Hyun-Hoon
Song Yong-Sang
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Abstract
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Over the past decades, prognosis of advanced stage epithelial ovarian cancer remains very poor, despite the development of new chemotherapeutic drugs, as well as molecular targeted agents. Late presentation and frequent chemoresistance account for the poor prognosis. Emerging studies have shown that many genetic changes, especially p53 mutation, are associated with the chemoresistance. However, recent failure of the clinical trials using p53 gene-therapy makes researchers discuss the possible reasons for the failure. Epigenetic changes are considered one of the substantial reasons. Successful restoration of the aberrant epigenetic changes may be a promising strategy for overcoming chemoresistance in epithelial ovarian cancer. Herein, we will summarize the rationale for epigenetic therapy of cancer and current status of epigenetic studies in relation to chemoresistance in epithelial ovarian cancer.
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KEYWORD
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Epithelial ovarian cancer, Chemoresistance, Epigenetic therapies, P53
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